On inquiring ideas of epidemic proportions...

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Friday, January 19, 2007

Most Important Medical Advance Since 1840: Sanitation in BMJ Poll

From 5-14 January 2007, the British Medical Journal (BMJ) conducted an online poll to decide the most important medical advance since 1840 (the founding year of the BMJ, somewhat pretentious of a cutoff year). From a list initially suggested by BMJ readers, an expert panel chose the top 15, which formed the basis for the vote.

After all votes were tallied, Sanitation emerged as the winner. Although it sounds ho-hum and not as sexy as "vaccines" or "discoverty of DNA", Mackenbach pointed out (source: BMJ) that crowding and disease actually led to a decrease in life expectancy in Britain in the first half of the 19th century until sewage disposal and clean water systems arrived to reverse it. However, 37.7% of the votes casted were from the UK, 24% were members of the general public or the press, according to the BMJ.

Cast your own vote in the EPIDEMIOLOGY FORUM poll about "What is the most important medical advance."

Results of public BMJ poll of the top 15 medical advances since 1840, from over 11,000 votes.

Most Important Medical Advance Since 1840: Sanitation and Public Hygiene

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Monday, January 15, 2007

Refuting Franklin and Thurber: Early to Bed, Early to Rise to Make Men Healthy, Wealthy, and Wise?

Although Benjamin Franklin has contributed much to modern society both as a scientist and a statesman, it is still not known whether his phrase of wisdom, "Early to bed, early to rise, makes a man healthy wealthy and wise" is supported by clinical evidence. Furthermore, it has been argued by James Thurber that in fact "Early to rise and early to bed makes a man healthy and wealthy and dead".

Fortunately, to help answer this earth-shattering dilemma, a team of researchers from Boston explored the Franklin and Thurber hypotheses in a recent issue of the Canadian Medical Association Journal. They examined the associations of sleeping patterns with morbidity, educational attainment and income level in 949 men. Their directly concluded that "Our results refute both the Franklin and Thurber hypotheses. Early to bed and early to rise is not associated with health, wealth or wisdom".

I am certain as result of this groundbreaking study that billions of men can now rest each night and sleep soundly and not have excessive guilt waking up the next morning.

Next step: replication this study in women-- afterall Franklin and Thurber had only made conjectures about men and not women. Perhaps these 18th early 20th century wisemen were a bit sexist and were not concerned about the health and wealth of women who were expected to wake up earlier and prepare breakfast for their husbands and household masters each morning.

Reference: Mukamal KJ, Wellenius GA, Mittleman MA. Early to bed and early to rise: does it matter? CMAJ. 2006 Dec 5;175(12):1560-2.

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Saturday, January 13, 2007

What is Epidemiology and Other Basic Concepts in Epidemiology

What is Epidemiology?
The textbook definition of epidemiology is: "The study of the distribution and determinants of diseases in human populations". Less formally, epidemiology is the scientific method used to track population health and to find causes of disease (and health) in groups of people. It is often called the basic science of public health, but its principles extend to clinical research.

Epidemiologists study causes and patterns of:

  • chronic diseases (e.g., heart disease, cancer and diabetes)
  • infectious diseases (e.g., flu and HIV)
  • illnesses that result from environmental exposures to such agents as chemicals or pollutants
  • illnesses that are related to genetic traits (e.g., cystic fibrosis, certain cancers)
  • injuries (e.g., workplace injuries, injuries from violence and car accidents)
  • mental illnesses (e.g., depression and schizophrenia)
  • the risks and benefits of drugs

What Do Epidemiologists Do?
Epidemiologists improve the public’s health by studying causes of and solutions for population-wide health problems. The responsibilities of an epidemiologist may range from finding factors that affect a community’s health to carrying out sophisticated, scientific research using the most advanced techniques of modern molecular biology and genetics. On a typical day, an epidemiologist might spend time:

  • designing a health study
  • collecting or analyzing data
  • writing reports
  • speaking to the public and colleagues about research findings

Epidemiologists work in many different settings, including:
  • state or local health departments
  • government agencies such as: the Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), or the National Institutes of Health (NIH)
  • universities and academic institutions, such as schools of public health and schools of medicine
  • private companies such as pharmaceutical corporations
  • consulting firms
  • international agencies like the World Health Organization

What Is an Epidemic?
Epidemiologists define an epidemic as any unusual occurrence of disease, generally first noticed by an unexpected number of cases occurring over a particular amount of time or in a particular place. During the course of an epidemic, epidemiologists work to identify the disease and its causes. For example, the surprising number of cases of a deadly form of pneumonia in China led to the identification of SARS and the virus that causes SARS.

We usually think about epidemics as acute events that take place rapidly and cause a dramatic increase in the numbers of deaths. Epidemics, however, can also be slow, or chronic—but equally deadly. Over the last 100 years, for example, there has been an ever-accelerating epidemic of lung cancer caused by cigarette smoking. Lung cancer had been rare at the start of last century, but at the century’s end, high rates of smoking had made the disease a common killer. Epidemiologists use the same methods to study both acute epidemics and chronic epidemics.


What Is a Pandemic?
A pandemic is an epidemic occurring over a very wide area, crossing international boundaries and usually affecting a large number of people. It is the term for a global epidemic. Due to its impact around the world, HIV/AIDS is considered a pandemic. The 1918 influenza is another example of a pandemic. Pandemics do not have to be caused by infectious diseases. The spread of health behaviors can create pandemics as well. For example, the increase in cigarette smoking around the world has led to a pandemic of lung cancer.

Epidemiologists are concerned about pandemics because the increased amount of travel in recent years and the speed at which people can travel from country to country would almost certainly help disease to spread faster than in the past.

(referenced from the Johns Hopkins Bloomberg School of Public Health)

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Top Ranked Scientists in Clinical Medicine and Epidemiology

Although there are a number of indices of scientist impact and success, such as the H-index or the impact factor of journals in which authors publish--the overall impact and influence of a scientist can still be most easily summarized by the total number of citations a scientist's published papers receive. The total citations count is indeed how ISI ranked the top scientists in clinical medicine in the past decade 1995-2005.

Below are the rankings of the most-cited authors in clinical medicine (Source: ISI Essential Science Indicators), as well as ranking by the top sub-fields of epidemiology, cardiology, oncology, and general biomedicine.


Overall Ranking: Clinical Medicine
(Epidemiology, Cardiology, Oncology, General Biomedicine, etc.)
Meir J. Stampfer Walter C. Willett Charles H. Hennekens Bert Vogelstein Kenneth W. Kinzler Graham A. Colditz Robert M. Califf John C. Reed Eric J. Topol JoAnn E. Manson Paul M. Ridker Eugene Braunwald Peter J. Barnes Frank E. Speizer Daniel Levy Salim Yusuf Richard Peto Rory Collins Peter Libby James G. Herman Harvard University University of Miami Howard Hughes Medical Institute Johns Hopkins University Duke University Burnham Institute Cleveland Clinic Foundation Imperial College London NHBLI Cardiology McMaster University University of Oxford




















Rankings by clinical medicine subfields:

Epidemiology

Meir J. Stampfer Walter C. Willett Charles H. Hennekens Graham A. Colditz JoAnn E. Manson Frank E. Speizer Richard Peto Rory Collins Jaakko Tuomilehto David J. Hunter Harvard University University of Miami University of Oxford University of Helsinki











Cardiology
Robert M. Califf Eric J. Topol Paul M. Ridker Eugene Braunwald Peter J. Barnes Daniel Levy Salim Yusuf Peter Libby Jeffrey M. Isner Curt D. Furberg Duke University Cleveland Clinic Harvard University Imperial College London NHLBI McMaster University Tufts University Wake Forest University











Oncology

Bert Vogelstein Kenneth W. Kinzler James G. Herman Stephen B. Baylin David Sidransky Judah Folkman Adrian L. Harris Ralph H. Hruban Phyllis A. Wingo Waun Ki Hong Howard Huges Medical Institute Harvard University University of Oxford Johns Hopkins University American Cancer Society University of Texas M.D. Anderson Cancer Center











General Biomedicine

John C. Reed Patrick O. Brown Guido Kroemer Shigekazu Nagata Yuji Matsuzawa Jerry W. Shay Douglas R. Green Peter Carmeliet Désiré Desire Collen David Botstein Howard Huges Medical Institute Burnham Institute Stanford University Institute Gustave-Roussy Osaka University University of Texas Southwestern La Jolla Institute University of Leuven Princeton University


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Thursday, January 11, 2007

Leading U.S. Cancer Centers

Below is a comprehensive list of the top 61 national cancer treatment and research centers in the United States that are official NIH National Cancer Institute affiliated:


Alabama


UAB Comprehensive Cancer Center

Arizona

Arizona Cancer Center

California

City of Hope National Medical Center & Beckman Research Institute

Salk Institute

The Burnham Institute

Rebecca and John Moores UCSD Cancer Center

Jonsson Comprehensive Cancer Center

USC/Norris Comprehensive Cancer Center

Chao Family Comprehensive Cancer Center

UC Davis Cancer Center

UCSF Comprehensive Cancer Center & Cancer Research Institute

Colorado

University of Colorado Cancer Center

Connecticut

Yale Cancer Center

Florida

H. Lee Moffitt Cancer Center & Research Institute

Hawaii

Cancer Research Center of Hawaii

Illinois

University of Chicago Cancer Research Center

Robert H. Lurie Comprehensive Cancer Center

Indiana

Indiana University Cancer Center

Purdue University Cancer Center

Iowa

Holden Comprehensive Cancer Center

Maine

The Jackson Laboratory

Maryland

The Sidney Kimmel Comprehensive Cancer Center

Massachusetts

Dana-Farber/Harvard Cancer Center

Center for Cancer Research

Michigan

Comprehensive Cancer Center

The Barbara Ann Karmanos Cancer Institute

Minnesota

University of Minnesota Cancer Center

Mayo Clinic Cancer Center

Missouri

Siteman Cancer Center

Nebraska

University of Nebraska Medical Center/Eppley Cancer Center

New Hampshire

UNM Cancer Research & Treatment Center

New Jersey

The Cancer Institute of New Jersey

New Mexico

UNM Cancer Research & Treatment Center

New York

Cancer Research Center

Roswell Park Cancer Institute

Cold Spring Harbor Laboratory

NYU Cancer Institute

Memorial Sloan-Kettering Cancer Center

Herbert Irving Comprehensive Cancer Center

North Carolina

UNC Lineberger Comprehensive Cancer Center

Duke Comprehensive Cancer Center

Comprehensive Cancer Center

Ohio

Case Comprehensive Cancer Center

Comprehensive Cancer Center

Arthur G. James Cancer Hospital & Richard J. Solove Research Institute

Oregon

OHSU Cancer Institute

Pennsylvania

Abramson Cancer Center

The Wistar Institute

Fox Chase Cancer Center

Kimmel Cancer Center

University of Pittsburgh Cancer Institute

Tennessee

St. Jude Children's Research Hospital

Vanderbilt-Ingram Cancer Center

Texas

M.D. Anderson Cancer Center

San Antonio Cancer Institute

Utah

Huntsman Cancer Institute

Vermont Cancer Center

Virginia

UVa Cancer Center

Massey Cancer Center

Washington

Fred Hutchinson Cancer Research Center

Washington, D.C.

Lombardi Cancer Research Center

Wisconsin

Comprehensive Cancer Center

Source: National Institutes of Health- National Cancer Institute

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